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The part of a prescription containing the directions to the patient. [Mediev. L. signatura, fr. L. signum, a sign, mark]
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1) a feature in the appearance or qualities of a natural object formerly held to indicate its utility in medicine either because of a fancied resemblance to a body part (as a heart-shaped leaf indicating utility in heart disease) or because of a presumed relation to some phase of a disease (as the prickly nature of thistle indicating utility in case of a stitch in the side)
2) the part of a medical prescription which contains the directions to the patient
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sig·na·ture (sigґnə-chər) [L. signatura] 1. the part of a prescription that gives directions to the patient for taking of medicine; abbreviated S. or sig. See prescription. 2. a characteristic feature of a substance that in folk medicine may be regarded as an indicator of its medicinal virtues: the eyelike mark on the flower of the euphrasia was considered to show its usefulness in eye diseases; the liverlike shape of the leaf of liverwort pointed to its use in hepatic diseases; and the yellow color of saffron indicated its use in jaundice.Medical dictionary. 2011.