Condensation product of a carboxylic acid and coenzyme A; metabolic intermediate of importance, notably in the oxidation and synthesis of fat. SYN: acyl-coenzyme A.
- acyl-CoA dehydrogenase (NADPH) enzyme catalyzing the reversible reduction of enoyl-CoA derivatives of chain length 4–16, with NADPH as the hydrogen donor, forming acyl-CoA and NADP+. SYN: enoyl-CoA reductase.
- acyl-CoA synthetase 1. general term for enzymes (EC 6.2.1.x) that form acyl-CoA, now called ligases; 2. specifically, long-chain fatty acid –CoA ligase.
Medical dictionary. 2011.