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(VLDL) a class of lipoproteins that transport triglycerides from the intestine and liver to adipose and muscle tissues. Synthesized by the liver, they contain primarily triglycerides in their lipid cores, with some cholesteryl esters; as their triglycerides are cleaved by endothelial lipoprotein lipase and transferred to extrahepatic tissues, the VLDL particles lose most of their apolipoprotein C and become intermediate-density lipoproteins. Called also (referring to electrophoretic mobility) pre-β-l.Medical dictionary. 2011.