macrophage colony-stimulating factor n a colony-stimulating factor produced by macrophages, endothelial cells, and fibroblasts that stimulates production and maturation of macrophages abbr. M-CSF
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(M-CSF) a colony-stimulating factor secreted by macrophages, stimulated endothelial cells, and most tissues, that stimulates the production of macrophages from precursor cells and maintains the viability of mature macrophages in vitro.Medical dictionary. 2011.