1. An enzyme present in raw fish that destroys thiamin and may produce thiamin deficiency in animals on a diet largely composed of raw fish. 2. A hydrolase cleaving thiamin into a pyrimidine moiety ( i.e., 2-methyl-4-amino-5-hydroxymethylpyrimidine) and a thiazole moiety ( i.e., 4-methyl-5-(2′-hydroxyethyl)thiazole); the pyrimidine moiety may appear in the urine as pyramin. SYN: t. II.
- t. I SYN: thiamin pyridinylase.
- t. II SYN: t. (2).
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thi·ami·nase thī-'am-ə-.nās, 'thī-ə-mə-, -.nāz n an enzyme that catalyzes the breakdown of thiamine
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thi·am·i·nase (thi-amґĭ-nās) [EC 3.5.99.2] an enzyme of the hydrolase class that catalyzes the cleavage of thiamine into its component pyrimidine and thiazole moieties, inactivating it. The enzyme is present in intestinal microorganisms. Called also t. II.Medical dictionary. 2011.