Lacking an antibody of a specific type in serum; used to mean absence of prior infection with a specific agent ( e.g., rubella virus), disappearance of antibodies after treatment of a disease ( e.g., syphilis), or absence of antibody usually found in a given syndrome ( e.g., rheumatoid arthritis without rheumatoid factor).
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se·ro·neg·a·tive -'neg-ə-tiv adj having or being a negative serum reaction esp. in a test for the presence of an antibody <early \seronegative syphilis> <a \seronegative patient>
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se·ro·neg·a·tive (sēr″o-negґə-tiv) serologically negative; showing negative results on serological examination; showing a lack of antibody.Medical dictionary. 2011.