Akademik

A graphical representation.

- double-reciprocal p. a graphic representation of enzyme kinetic data in which 1/v (on the vertical axis), where v is the initial velocity, is plotted as a function of the reciprocal of the substrate concentration (1/[S]). SYN: Lineweaver-Burk p., Woolf-Lineweaver-Burk p..

- Eadie-Hofstee p. a graphic representation of enzyme kinetic data in which velocities, v, are plotted on the vertical axis as a function of the v/[S] ratio on the horizontal axis. On occasion, these axes are reversed. Sometimes referred to as the Eadie-Augustinsson p. or Woolf-Eadie-Augustinsson-Hofstee p..

- funnel p. a graphic method of detecting publication bias. The estimate of risk derived from a set of epidemiologic studies used in a metaanalysis is plotted against sample size. If there is no publication bias, the p. is funnel-shaped; if studies giving significant results are more likely to be published than negative studies, the p. is asymmetric. SEE ALSO: metaanalysis.

- Hanes p. a graphic representation of enzyme kinetic data in which the substrate concentration divided by the velocity ( i.e., the [S]/v ratio) is plotted on the vertical axis as a function of [S]. Sometimes referred to as the Hanes-Wilkinson p..

- Hill p. a graphic representation of enzyme kinetic data or of binding phenomena to assess the degree of cooperativity of a system; the vertical axis in a Hill p. is log [Y/(1 − Y)], in which Y is the degree of saturation (for enzymes, the vertical axis is log [v/(V_max − v)], where v is the initial velocity and V_max is the maximum velocity, and the horizontal axis is the logarithm of the ligand concentration.

- Lineweaver-Burk p. SYN: double-reciprocal p..

- Ramachandran p. a graphic representation in which the dihedral angle of rotation about the α-carbon-to-carbonyl-carbon bond in polypeptides is plotted against the dihedral angle of rotation about the α-carbon-to-nitrogen bond. SYN: conformational map.

- Scatchard p. 1. a graphic representation used in the analysis of binding phenomena in which the concentration of bound ligand divided by the concentration of free ligand is plotted against the concentration of bound ligand; 2. similar to (1), except the concentration of the bound ligand is on the vertical axis.

- Woolf-Lineweaver-Burk p. SYN: double-reciprocal p..