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opac·i·fi·ca·tion ō-.pas-ə-fə-'kā-shən n an act or the process of becoming or rendering opaque <\opacification of the cornea> <\opacification of the bile passages for radiographic examination>
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opac·i·fi·ca·tion (o-pas″ĭ-fĭ-kaґshən) 1. the development of opacity, as of the cornea or lens. 2. the rendering of a tissue or organ opaque to radiation by introduction of a contrast medium.Medical dictionary. 2011.