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man·ic-de·pres·sive .man-ik-di-'pres-iv adj characterized by or affected with either mania or depression or alternating mania and depression (as in bipolar disorder)
manic-depressive n a manic-depressive individual
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man·ic-de·pres·sive (manґik-de-presґiv) alternating between attacks of mania and depression, as in bipolar disorder.Medical dictionary. 2011.