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mal·as·sim·i·la·tion (mal″ə-sim″ĭ-laґshən) [L. malus ill + assimilation] 1. imperfect, faulty, or disordered assimilation. 2. inability of the gastrointestinal tract to transport to the body fluids one or more ingested nutrients, whether due to faulty digestion (maldigestion) or to impaired intestinal mucosal transport (malabsorption).Medical dictionary. 2011.