A congenital form of dwarfism characterized by extreme growth retardation, endocrine disorders, and emaciation, with elfin facies and large, low-set ears; autosomal recessive inheritance; caused by mutation in the insulin receptor gene (INSR) on 19p. SYN: Donohue disease, Donohue syndrome. [Irish leprechaun, elf]
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lep·re·chaun·ism 'lep-rə-.kän-.iz-əm, -.kȯn- n a rare inherited disorder characterized by mental and physical retardation, by endocrine disorders, by hirsutism, and esp. by a facies marked by large wide-set eyes and large low-set ears
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lep·re·chaun·ism (lepґrə-kon″iz-əm) Donohue syndrome.Medical dictionary. 2011.