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ho·lo·en·dem·ic .hō-lō-en-'dem-ik adj affecting all or characterized by the infection of essentially all the inhabitants of a particular area <\holoendemic diseases>
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holo·en·dem·ic (hōl″o-en-demґik) [holo- + endemic] endemic at a high level early in life in a population and leading to a state of equilibrium such that the adult population shows evidence of the disease less often than do the children. Cf. hyperendemic.Medical dictionary. 2011.