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hep·a·top·to·sis (hep″ə-top-toґsis) (hep″ə-to-toґsis) [hepato- + -ptosis] 1. downward displacement of the liver, such as from laxness of suspensory ligaments, diminished tone of abdominal muscles, emphysema, right pleural effusion or empyema, subphrenic abscess, or spinal deformity. 2. Chilaiditi sign.Medical dictionary. 2011.