The innermost connective tissue supportive structure of nerve trunks, that surrounds both myelinated and unmyelinated nerve fibers; consists principally of ground substance, collagen, and fibroblasts; with the perineurium and epineurium, comprises the peripheral nerve stroma. SYN: Henle sheath, sheath of Key and Retzius. [endo- + G. neuron, nerve]
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en·do·neu·ri·um .en-dō-'n(y)u̇r-ē-əm n, pl -ria -ē-ə the delicate connective tissue network holding together the individual fibers of a nerve trunk
en·do·neu·ri·al -ē-əl adj
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n.
the layer of fibrous tissue that separates individual fibres within a nerve.
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en·do·neu·ri·um (en″do-noorґe-um) [endo- + Gr. neuron nerve] [TA] the innermost layer of connective tissue in a peripheral nerve, forming an interstitial layer around each individual fiber outside the neurilemma; called also epilemma, Henle sheath, and sheath of Key and Retzius. See also epineurium and perineurium. endoneurial adjMedical dictionary. 2011.