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an·ti·nu·cle·ar -'n(y)ü-klē-ər adj being antibodies or autoantibodies that react with components and esp. DNA of cell nuclei and that tend to occur frequently in connective tissue diseases (as systemic lupus erythematosus, rheumatoid arthritis, and Sjögrens syndrome)
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an·ti·nu·cle·ar (an″te-) (an″ti-nooґkle-ər) destructive to or reactive with components of the cell nucleus, as antinuclear antibody.Medical dictionary. 2011.